Molecular Genetics

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• Many RNA transcripts are altered before they function in cell metabolism. A variety of alterations are known:
  • splicing;
  • nucleolytic cleavage;
  • cap addition
  • polyA addition
  • base and sugar modification
  • editing
• Destruction of active mRNAs is an alteration that removes the mRNA from function in cell metabolism.

• RNA processing may be coupled to transcription