Initiation of translation in eukaryotes and prokaryotes share
numerous features, but differ in others:
- The AUG codon is the principal initiation codon in eukaryotes and prokaryotes.
- It is recognized by a special tRNA for methionine.
- The met tRNA is N-formylated in prokaryotes, but not eukaryotes.
- A special context helps select the correct AUG in eukaryotes and prokaryotes.
- Most initiation events in eukaryotes require the capped 5' end, while in prokaryotes the 5' end is unimportant for initiation.
- Polycistrony is common in prokaryotes and known, but rare, eukaryotes
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This is page 243 of Molecular Genetics by Ulrich Melcher, © 1997, 1998
E-mail inquiries to U. Melcher------------Last Updated: 4 November, 1998