Genomes in Flux
Genome projects targeted at sequencing an organism's DNA provide a static picture of the genome of one individual (or an amalgam of individuals). Actually, genomes are in a constant state of flux. Sources of genome change include:
- DNA damage, repair, and mutation. Mutations arise through damage to DNA that has not been repaired.
- DNA rearrangements. Site-specific recombination and transposition mediated rearrangements require recognition of a specific target sequence.
- Genome invasion. DNA from other organisms can become established within an organism's genome.
- Gene and sequence amplification. Short or long sequences may, under certain conditions, become amplified many fold.
- Recombination. Exchange occurs between homologous DNA sequences.
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This is page 3 of Molecular Genetics by Ulrich Melcher, © 1997
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