Molecular Genetics

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Multiple systems for repairing damage to DNA have evolved, probably because of the importance of the DNA information content.

Direct DNA damage reversal Base excision repair Nucleotide excision repair Mismatch repair Double-strand break repair

Repair of DNA damage is coupled to other processes in cells

• Cell division does not happen until damage is repaired.
• Transcription signals a strand-preferential repair.
• Recombination and DNA repair can be induced by DNA damage.

DNA damage repair processes can be recruited for biotechnology purposes by chimeroplasty.

This is page 313 of Molecular Genetics by Ulrich Melcher, © 1997, 1998, 1999